First Observation of Hemoglobin Kansas [β102(G4)Asn→Thr, AAC>ACC] in the Turkish Population.
نویسندگان
چکیده
1. Aydogdu I, Erkurt MA, Ozhan O, Kaya E, Kuku I, Yitmen E, Aydin NE. Reversible bone marrow necrosis in a patient due to overdosage of diclofenac sodium. Am J Hematol 2006;81:298. 2. Bhasin TS, Sharma S, Chandey M, Bhatia PK, Mannan R. A case of bone marrow necrosis of an idiopathic aetiology: the report of a rare entity with review of the literature. J Clin Diagn Res 2012;7:525-528. 3. Rosenbaum H. Hemorrhagic aspects of Gaucher disease. Rambam Maimonides Med J 2014;5:e0039.
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Nucleotide sequence of the gtfA gene from S. mutans GS-5.
5' AAGCTTCCAC TACCTTGCCA CCCGCAATAA GAACGATTAC TTCTCCCTCG CCTT 54 Kec Pro tie Thr Asn 141 CTACCA CCTAAAGATC TCCCTCTTAT TTTTAGOTTG AACTCGTATA AACCAAAATT AATTACACCA GATAAA ATG CCA ATT ACA AAT -35 -10 BBS fut Lys ThT Hec Leu Il« Thr Tyr Ala Aap Ser Leu Gly Lye Asa Leu Lys Glu Leu Asn Glu A«n H e Glu Agn Tyr AAA ACA ATG TTC ATT ACT TAC GCA CAC ACT TTC OGT AAA AAT TTG AAA CAA TTG AAT GAA AAT ATT GAG...
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We identified two new variants in the third exon of the α-globin gene in families from southern Italy: the Hb Rogliano, α1 cod108 ACC>AAC or α1[α108(G15)Thr→Asn] and the Hb Policoro, α2 cod124 TCC>CCC or α2[α124(H7)Ser→Pro]. The carriers showed mild α-thalassemia phenotype and abnormal hemoglobin stability features. These mutations occurred in the G and H helices of the α-globin both involved i...
متن کاملHemoglobin Richmond. Subunit dissociation and oxygen equilibrium properties.
In hemoglobin Richmond (beta102 leads to Lys), amino acid substitution has occurred at the same site as the mutation in hemoglobin Kansas (beta102 Asn leads to Thr), a variant with very low oxygen affinity. Although hemoglobin Richmond has been shown to have increased tetramer-dimer dissociation, its oxygen affinity has been inferred to be normal from studies on hemolysates of carriers. We have...
متن کاملKinetic and equilibrium properties of hemoglobin Kansas.
The reactions of hemoglobin Kansas (102 0 Asn + Thr) have been examined by kinetic and equilibrium methods. The behavior of the T state toward oxygen, derived from oxygen binding and oxygen pulse experiments, appears similar to that of hemoglobin A. The behavior of the R tetramer is difficult to separate from that of the dimer (the . . . dlssoclatlon constant, Kq, 2, for oxyhemoglobin Kansas is...
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ورودعنوان ژورنال:
- Turkish journal of haematology : official journal of Turkish Society of Haematology
دوره 32 4 شماره
صفحات -
تاریخ انتشار 2015